The following is an excerpt from the Report of Investigation from the Air Force
Office of Special Investigations at Wright-Patterson Air Force Base:
A hold was indicated for both prescriptions for drug interaction. The doctor overrode the warnings with the following comments, "used in combo." The overrides were
not further explained. A pharmacist and board certified pharmacotherapy specialist at Wright-Patterson Air Force Base confirmed
that MSG Kinamon was prescribed Roxicet in combination with Duragesic (fentanyl transdermal patch) and explained Roxicet and
Duragesic were both considered central nervous system (CNS) depressants. Patients were not typically monitored for initial
administration of fentanyl transdermal patches, but the pharmacist confirmed the
combined therapy of multiple CNS depressants increased the risk of respiratory depression and monitoring the patient
during initial dosage administration was advisable. The pharmacist described
the doctor's fentanyl dosage of 75 mcg/h as high for MSG Kinamon. The pharmacist stated initial dosages typically
started at 25 mcg/h. Additionally, the pharmacist did not consider MSG Kinamon to
be opioid tolerant. The U.S. Food and Drug Administration (FDA) issued an advisory in July 2005, in which they highlighted
the fentanyl patches should not be used to treat pain after an operation and should only be used on opioid tolerant patients.
A review of full prescribing information for Duragesic (fentanyl transdermal system) revealed Duragesic is prescribed for
management of persistent, chronic pain and is not recommended in the management of post-operative pain. Duragesic should only
be used in patients who are already receiving opioid (narcotic pain killer) therapy and have demonstrated opioid tolerance;
use in non-opioid tolerant patients may lead to fatal respiratory depression. Overestimating the dose can result in fatal
overdose with the first dose. Use of Duragesic should be monitored during the initial 24-72 hours when serum concentrations
peak from the initial patch. (emphasis added)
Per
the report, the matter being investigated was "negligent homicide." Even though there were numerous references to
the inappropriate prescribing of the Duragesic and Roxicet, no action was taken against Dr. Tibesar.
In summary, Dr. Tibesar was not charged with negligent homicide under the Uniform Code of Military Justice, can not
be criminally charged by the State of Ohio unless the military requests that state and local authorities be involved in the
case, can not be sued in civil court because of the Feres doctrine, and has not been disciplined by his state licensing
board.